Technology

PIONEERING INNOVATION

in 3D Printed Interbody Fusion Technology

REDUCED STIFFNESS

Subsidence Risk Reduction with Soft Titanium Implants

97% Less stiff than solid titanium implants

Modulus similar to PEEK

bone

Hive IMPLANTS

PEEK

TITANIUM
IMPLANTS

COMPARISON OF ELASTIC MODULUS

Durable Load Bearing Lattice

Patented low stiffness core prevents stress shielding

Stimulates and strengthens bone formation as described by Wolff's Law

SUPERIOR IMAGING

Visualization Available Across All Devices

Hive™ implants preferred by four out of five surgeons over competitive devices in an independent blind study of visualization characteristics.

Optimal aid to assess implant positioning

Endplate fusion readily identifiable on x-ray

Easily visualize bone growth through cage

Minimal scatter on CT and MRI scans

INGROWTH

The First Step to Fusion

µCT with bone-density color overlay.

LAPINE MODEL: 8 WEEKS DATA ON FILE

Pore sizes of 300 to 700 microns shown to be optimal for new bone attachment

70% porous, allowing bony ingrowth

Open pore structure allows flow of cells and signals

Lattice observed to promote bone growth prior to autograft

ONGROWTH

MACRO

SUB-MICRO

MICRO

Increased osteoblast recruitment compared to untreated surfaces [1]

Rapid bone attachment at endplates and throughout lattice [2]

Complex sub-micron surface increases osteoblast proliferation [1,3]

Soft Titanium lattice provides up to 20x more surface area

Faster implant stability from on-growth at host bone interface

[1] N. J. Bassous, C. L. Jones and T. J. Webster, 3-D printed Ti-6Al-4V scaffolds for supporting osteoblast and restricting bacterial functions without using drugs:
Predictive eQuations and experiments, Acta Biomaterialia 96 (2019) 662–673, https://doi.org/10.1016/j.actbio.2019.06.055,
[2] CL Jones, D Bichara, J Toy, J Tinley. (2018) "Bone In Growth with 3D-Printed Soft Titanium® Scaffold." [White Paper], HD LifeSciences, LLC.
[3] Ejiofor J., et al, Bone Cell Adhesion on Titanium Implants with Nanoscale Surface Features. International Journal of Powder Metallurgy, 40(2), 43-53.

NanoHive Medical, LLC (formerly HD Lifesciences, LLC) Virtual Patent Marking

The NanoHive Medical, LLC products listed below are protected by patents in the United States and elsewhere. This website is provided to satisfy the virtual patent marking provisions of various jurisdictions including the virtual patent marking provisions of the America Invents Act (September 16, 2011).

The following list of products may not be all inclusive, and any other product not listed here may be protected by one or more patents. The products listed may be protected by additional patents, and other patents may be pending in the U.S. and elsewhere.

- Hive C, TL, PL, AL & AL Standalone Interbody Systems

- Protected by U.S. Patents:

9,962,269; 10,405,983 (Implant with Independent Endplates)
10,888,429; 10,368,997 (Three Dimensional Lattice Structure for Implants)
10,695,184; 15/895,213 (Methods of Designing Lattice Structures)
15/895,213 (Methods of Designing Lucent Structures)
10,624,746 (Fluid Interface System for Implants)
10,881,518 (Anisotropic Biocompatible Lattice Structure)
16/523,962 (Cervical Stand Alone)

TECHNOLOGY